Do T-cells swim?

Aaron Warnock ebutcher awarnock at leland.Stanford.EDU
Tue Sep 6 20:46:56 EST 1994


Well, no, they don't swim. But they do tumble, roll, stick, flatten,
ruffle, squeeze, and crawl. For more info on what's known, please
check out at least the following:

Springer TA.
      Traffic signals for lymphocyte recirculation and leukocyte emigration:
      the multistep paradigm.
    Cell, 1994 Jan 28, 76(2):301-14.
      (UI:  94123337)
      Pub type:  Journal Article; Review; Review, Academic.

Jutila MA.
      Function and regulation of leukocyte homing receptors.
    Journal of Leukocyte Biology, 1994 Jan, 55(1):133-40.
      ABSTRACT available.  (UI:  94110734)
      Pub type:  Journal Article; Review; Review, Tutorial.

Later,

Aaron


In article <34de3r$973 at scratchy.reed.edu>,
Aaron J Mackey <amackey at reed.edu> wrote:
>In article <CvICoL.1KMr at hawnews.watson.ibm.com>,
>John Barton <jjb at watson.ibm.com> wrote:
>>  I have read many accounts of the chemical signals sent to
>>alert the components of the immune system.  Unfortunately, such
>>articles never seem to specify how the system localizes response.
>>Does the immune system flood the body with T-cells and rely on
>>statitisical encounters and local activation or do T-cells get up 
>>and hike over to the fire?
>>
>>-- 
>>John.
>>
>>John J. Barton        jjb at watson.ibm.com            (914)784-6645
>>H1-C13 IBM Watson Research Center P.O. Box 704 Hawthorne NY 10598
>
>In article <3481eb$l90 at agate.berkeley.edu> you write:
>>Although T cells probably cannot "swim", as we think of it (i.e. move 
>>directionally when suspended in liquid), they definitely can crawl.  T cells
>>use pseudopodia (like amoebae) to move along a surface.  Thus, a T cell that
>
>Really? I have never heard of this before, do you have reference to this
>phenomenon you could forward to me, I would be much interested.
>
>>is in a small capillary can crawl along the inner surface toward a signal, 
>>and T cells that are in other tissues (as in an immune response) can use the
>>extracellular matrix as a crawling surface.
>>
>>BioKen
>
>I think an even better answer to the question is the fact that T cells have 
>cell surface markers which act as homing devices to certain tissues.  An
>activated T cell may up regulate its expression of a certain cell surface
>receptor which allows it to travel through the blood stream until it reaches
>the site of action, i.e. a directed statistical encounter in the sense that
>the binding affinity of the homing molecule will assure that the cell binds
>where it is supposed to and no where else.
>
>Just my two cents worth.
>
>Aaron Mackey
>Reed College
>Portland, OR 97202
>>
>>-- 
>>Ken Frauwirth (MiSTie #33025)  _           _
>>frauwirt at mendel.berkeley.edu  |_) *    |/ (_ |\ |
>>Dept. of Molec. & Cell Bio.   |_) | () |\ (_ | \|  
>>Univ. of Cal., Berkeley       "Well, I isolated that nucleotide today."
>
>





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