Tumor immunology

rjanssen_imm at opal.tufts.edu rjanssen_imm at opal.tufts.edu
Tue Sep 13 16:39:49 EST 1994

In article <34tjd6$755 at jhunix1.hcf.jhu.edu>, ejf at welchlink.welch.jhu.edu (Ephraim Fuchs) writes:
> I do not believe in immunosurveillance because tumors arise from cell 
> types that cannot provide a costimulatory signal for naive T cell 
> activation.
Thinking along this statement, there would be no immunedefense against virally
infected cells as well. But there is clearly an immunedefense against virally
infected cells which do not express accessory molecules. So I think the above
statement does not lead to the conclusion that there is no immunosurveilance.
However, the absence of costimulatory signals is indeed a big problem for those
who want to perform immunotherapy.

Richard Janssen
Hema/Onco NEMC

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