TcR--one or two binding sites

Mark Hodes markhodes at
Sat Sep 17 23:32:05 EST 1994

Jonathan Sprent in Paul, Ch.3, writes that it's an open question whether
TcR has two adjacent binding sites:  one for self MHC and one for foreign
peptide or has one binding site for MHC+peptide complex.  Diagrams in
Benjamin & Leskowitz (1993), in Paul (1993) ch. 1, and Sprent in Paul,
Ch.3, all seem to accept the second view.  Comments?    Mark Hodes
(markhodes at

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