Why MHC Class I and II molecules?
markhodes at aol.com
Sun Sep 25 23:16:05 EST 1994
In article <36584i$306 at jhunix1.hcf.jhu.edu>, ejf at welchlink.welch.jhu.edu
(Ephraim Fuchs) writes:" Does anyone wish to speculate why there should be
two types of MHC
molecules (MHC Class I and MHC Class II) with different tissue
If evolution has taught us anything, it is that organisms are kludges.
Ted H. Hansen, et al in Paul (Fund. Imm. 19943) lists the following
immunological properties associated with the MHC:
1 vigorous rejection of tissue grapfts
2 stimulus of Ab production
3 stimulation of MLR
4 GVH reactions
6 Ir genes
7 restriction of immune response
8 Ag presentation to T cells
Even excluding 1 & 4 as adaptations leaves diverse properties
which may have "piggybacked" when adaptations serving one
function were exploited as preadaptations for others.
But then gene duplication coupled with differential
suitability to task could fix genetic divergences until
separate MHC types evolved. Differential suitability to task
may be exemplified by MHC I molecules presenting peptides from
endogenously derived proteins and MHC II exogenous proteins.
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