Th1/Th2

Fishman Michael michael at wiscon.weizmann.ac.il
Wed Apr 5 07:22:15 EST 1995


Hi people.

Somebody (not Derek V. Chan) posted the enclosed.
I would like to contact the author.

Thanks, Michael

>>I must redeem myself.  I believe there are Th2 and Th1 tendencies in CD4
>>T cells.  I just do not believe it is so cut and dry as the murine
>>leishmaniaisis data suggests.  We work in human T cells and find a
>>rainbow of T cells producing tons of gINF and no IL-4 all the way to tons
>>of IL-4 and low gIFN.  But 95% of the cells are in between.  and If you
>>look broader at IL4,5,6,10 etc... you see that when IL4 is high IL5 or 10
>>may not be and vice versa.  does this mean we have Th3 or th6 cells.
>>NOOOOOOO.  What we have are independently regulated cytokine genes.  Our
>>lab has shown for instance that gIFN is increased by IL-12
>>administration.  Therefore even a Th2 looking cell will make tons of gIFN
>>if IL-12 is added.  In that same paper we show that IL-12 added at the
>>time of first priming actually stabally increases IFN production-for the
>>life of the cell.
>>So, what I am saying is the following.  Don't be too dogmatic with this
>>Th1 vs 2 thing.  Th0 is used to explain these intermediates but it is
>>much messier.  I have begun to present my clonal data in linear form
>>assigning the clones a gINF/IL4 ratio of production.  Therefore a Th1
>>like cell will be a 600 and a Th2 a .3.  You get the picture.



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