POSTDOC POSITION IMMUNOLOGY, MELBOURNE

harrison at wehi.edu.au harrison at wehi.edu.au
Thu Apr 6 01:53:19 EST 1995


           THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH


                  POSITION FOR POST-DOCTORAL IMMUNOLOGIST,
                        BURNET CLINICAL RESEARCH UNIT


     Applicants should be interested in the relationship between peptide
structure and binding to disease-associated MHC molecules and ability to
stimulate or anergize T-cells. Experience with generating T-cell lines/clones
would be a decided advantage. Peptides will also be tested for their ability
to modify disease pathology and expression in animal models and studies
undertaken to define the mechanisms of therapeutic effects. Autoantigens 
and component peptides have already been administered intrathymically,
intravenously, orally and by aerosol with significant effects on disease
expression in the NOD mouse model of insulin-dependent diabetes, and
transmucosal delivery shown to be associated with the induction of regulatory
T-cells that inhibit disease/disease transfer. Peptide binding studies have 
been facilitated by the creation of the MHCPEP Database and by the application 
of formal prediction methods.

     The initial aim will be to further characterize binding peptides from
candidate autoantigens and generate T-cell lines/clones to them in order to
test the effect of peptide mutations on T-cell responsiveness. Work will be
undertaken within a multi-disciplinary group whose current interests encompass
the cellular and molecular pathology of insulin-dependent diabetes and
rheumatoid arthritis and the pre-clinical diagnosis and prediction of these
diseases, transgenic models of autoimmune disease, interferon action and
transcriptional regulation of MHC gene expression, gene therapy of auto- and
xeno-immune responses and the identification of beta cell growth factors.
Collaboration within and without the Unit is expected and encouraged.



Applicants should contact Prof. Harrison by E-mail ; harrison at wehi.edu.au



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