New Immune Theory
Peritt_d at a1.mscf.upenn.edu
Tue Apr 11 15:50:16 EST 1995
In article <3memhg$1mq at geraldo.cc.utexas.edu> B.L.T., writes:
>But how does this relate to antibody production to novel bacteria which
>have been heatkilled? Do B cells have to have this "danger signal", too,
>in order to differentiate and reproduce and more importantly, to produce
>appropriate antibodies. I would appreciate your response. Particularly,
>since I am currently attempoting to rank individuals with regard to
>their antibody responses to novel heatkilled bacteria.
>R. L. Thompson
Classically B cells need T cell help to make Ab to most Ags (T
dependent). Therefore the danger hypothesis may not need to involve B
cells at all only T. There is an ability to tolerize B cells but the
amount of peripheral B cell tolerance has not been clearly demonstrated.
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