New Immune Theory

David Peritt Peritt_d at
Tue Apr 11 15:50:16 EST 1995

In article <3memhg$1mq at> B.L.T.,  writes:
>But how does this relate to antibody production to novel bacteria which 
>have been heatkilled?  Do B cells have to have this "danger signal", too,
>in order to differentiate and reproduce and more importantly, to produce 
>appropriate antibodies.  I would appreciate your response.  Particularly,
>since I am currently attempoting to rank individuals with regard to 
>their antibody responses to novel heatkilled bacteria.
>R. L. Thompson

Classically B cells need T cell help to make Ab to most Ags (T
dependent).  Therefore the danger hypothesis may not need to involve B
cells at all only T.  There is an ability to tolerize B cells but the
amount of peripheral B cell tolerance has not been clearly demonstrated.

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