New Immune Theory
Tue Apr 11 14:50:08 EST 1995
In article <3mcrrc$mro at usenetw1.news.prodigy.com>, CVNW83A at prodigy.com (Richard Schultz) says:
What spurs the immune system, Matzinger says, is a shout of "danger" from
>cells dying in distress.
She like other researchers, notes that T-cells require a signal from
a critical white blood cell, called a dendritic
>cell, before they load their weapons and fire. Dendritic cells inhabit
>every tissue of the body, but they mostly lie dormant.
> To wake them up, cells nearby must call out in shock. "This
>[alert] is the initiation'" Matzinger declared at a recent Cancer
>Research Institute seminar in New York. "Without it, you don't get an
>immune response. Ever."
But how does this relate to antibody production to novel bacteria which
have been heatkilled? Do B cells have to have this "danger signal", too,
in order to differentiate and reproduce and more importantly, to produce
appropriate antibodies. I would appreciate your response. Particularly,
since I am currently attempoting to rank individuals with regard to
their antibody responses to novel heatkilled bacteria.
R. L. Thompson
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