New Immune Theory

B. B.
Tue Apr 11 14:41:03 EST 1995


In article <3mcrrc$mro at usenetw1.news.prodigy.com>, CVNW83A at prodigy.com (Richard Schultz) says:
What spurs the immune system, Matzinger says, is a shout of "danger" from 
>cells dying in distress.                 
>                           
>She ... like other researchers, notes that T-cells 
>require a signal from  a critical white blood cell, called a dendritic 
>cell, before they load their weapons and fire.  Dendritic cells inhabit   
>every tissue of the body, but they mostly lie dormant.
>
>       To wake them up, cells nearby must call out in shock. "This 
>[alert] is the initiation'" Matzinger declared at a recent   Cancer 
>Research Institute seminar in New York.  "Without it, you don't get an 
>immune response.  Ever."                   
>

If this is true, then why can you elicit lymphocyte differentiation and 
reproduction to heatkilled novel bacteria, et al.?  Or is the response 
only one of antibodies?  Are B cells differentially elicited?

I'd appreciate your response since I am currently challenging and ranking 
individuals' immonoresponsiveness by measuring antibody production to
heatkilled novel bacteria.

R. L. Thompson



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