New Immune Theory
B.
B.
Tue Apr 11 14:41:03 EST 1995
In article <3mcrrc$mro at usenetw1.news.prodigy.com>, CVNW83A at prodigy.com (Richard Schultz) says:
What spurs the immune system, Matzinger says, is a shout of "danger" from
>cells dying in distress.
>
>She ... like other researchers, notes that T-cells
>require a signal from a critical white blood cell, called a dendritic
>cell, before they load their weapons and fire. Dendritic cells inhabit
>every tissue of the body, but they mostly lie dormant.
>
> To wake them up, cells nearby must call out in shock. "This
>[alert] is the initiation'" Matzinger declared at a recent Cancer
>Research Institute seminar in New York. "Without it, you don't get an
>immune response. Ever."
>
If this is true, then why can you elicit lymphocyte differentiation and
reproduction to heatkilled novel bacteria, et al.? Or is the response
only one of antibodies? Are B cells differentially elicited?
I'd appreciate your response since I am currently challenging and ranking
individuals' immonoresponsiveness by measuring antibody production to
heatkilled novel bacteria.
R. L. Thompson
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