New Immune Theory

[Christopher J. Savoie]

To suggest that the foreign/non-foreign paradigm has weaknesses 
is quite interesting and probably true, but 
wouldn't a "threshold" model for acceptable levels
 of metabolic peptides also explain the response discrepancy as
 is suggested by Dr. Matzinge?  This would be more in line with the
 positive/negative selection processes and T-cell responses that have 
been demonstrated in transgenic animals.  A threshold model could also 
include thresholds for stress proteins such as heat shock products loaded
 onto MHC.