Which cells does HIV infect?
Immunobiology Research Institute, Siena
unutmaz at IRIS02.BIOCINE.IT
Thu Apr 13 02:47:07 EST 1995
Christopher Savoie (savoie at bioreg.kyushu-u.ac.jp) wrote:
:
: > There is no evidence that I know of showing direct CD8 infectivity.
: > CD4+8+ thymocytes can be infected but once they become single positive
: > they are presumably resistant.
Couple of years ago Robert Gallo's group reported that normal CD8+ T cells can be
made susceptible to infection with HIV-1 if they are first infected with human
herpesvirus 6 (HHV-6), which induces de novo expression of CD4 in CD8+ T cells.
(In fact HHV-6 has been proposed as a potential cofactor in AIDS). Whether this
infection is responsible for the defects observed in the CD8+ T cells in patients
with advanced HIV infection was not answered.
Ref: Nature 1991, 349:533
Derya
---------------------------------------------------------------------------------
Derya Unutmaz, M.D.
Immunobiology Research Institute
Via Fiorentina 1,
53100, Siena, Italy
E-mail: Unutmaz at iris02.biocine.it
Tel: +39-577-24 34 41
Fax: +39-577-24 35 64
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