A question of LPS

Dr Robin Barclay PhD 100066.300 at CompuServe.COM
Fri Dec 1 21:41:00 EST 1995


LPS (or Gram-negative bacterial endotoxin) is a potent activator 
of leucocytes - it interacts with LBP (LPS-binding-protein) in 
plasma and the complex triggers macrophages via their CD14 to 
release cytokines.  It is the primary pathogenic agent in septic 
shock, initiating an inflammatory chain reaction via a cytokine 
cascade.  There is a huge literature on this - get reading!



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