kimberla at teleport.com (Kimberla Kae Baertlein) wrote:
>I had some extensive lab workup on my on who is severly aflicted by his
>autism. I am going to list all his recent lab results and any comments
>or addtional input would be greatly appreciated. Here goes:
Dear Kimberla Kae,
Why did you have these test done in the first place?
I will try and give my comments. Now, I am a cellular immunologist which means
that I am not a clinician, but I think the serology results indicate that your
son have either recently suffered an infection (maybe without symptoms) or has
recently been vaccinated.
>>Immunology-Serology
>>Test Result Reference Range
>>IgM 71.5 (0.0-0.0)
>IgA 210 (33-200)
>IgE 162.7 (0.0-50.0)
>>>T-Lymphocyte Mitogen Proliferation Anaylsis
>>PHA% Index 100 Greater than 70% What is PHA?
>CON A% Index 83 " " What is CON?
>PWM% Index 84 " " What is PWM?
PHA, ConA and PWM are lectins, these are often used to indicate the maximal
stimulation of (peripheral blood) T cells. If these figures were low (which they
are not) this could mean that the T cells are functionally impaired as can be
observed in some autoimmune diseases (e.g. synovial fluid T cells of reumatoid
arthritis patients).
>Lymphocyte Antigen Proliferation Anaylisis
>>Candidia Stimulation Index 1.0 > or = 3.0
>Tetanus Stimualtion Index 5.4 > or = 3.0
>PPD Stimulation Index 0.6 > or = 3.0 What is PPD?
>
These antigens (PPD is purified protein derivative of Mycocaterium tuberculosis) are
used to assess the antigen-specific (as opposed to the a-specific lectin induced)
function of T cells. In this case only a mild response of your son's T cells to
tetanus toxoid is observed which is normal, as most people receive tetanus toxoid
boosts regularly.
>>T Lymphocytes
>% CD3 (Mature T Cells) 76 55-85%
>>B Lymphocytes
>% CD19 (Earliest B Cell) 15 5-25%
These percentages are normal
>>Pediatric Lymphocyte Enumeration Reference Ranges
>>Total WBC Count 6000-17500/CMM
>Total Lymphs (%of WBC) 50-70%
>Total Lymphocyte Count 3000-12250/CMM
>>T-Lymphocytes
>% CD3 (Mature T-Cells) 57-85%
>Absolute CD3 2040-6000/CMM
>>T-Lymphocyye Subsets
>%CD4 (Helper/Induver) 34-57%
>Absolute CD4 1300-4100/CMM
>%CD8 (Cytotoxic/Supressor) 18-42%
>Absolute CD8 750-2600/CMM
>CD4/CD8 Ratio 1.1-3.5
>B-Lymphocytes
>%CD19 19-26%
>Absolute CD19 610-1830
>>Any help with these lab results would be appreciated. Please reply to
>this post either by list or private...Whateever you choose. My email
>address is listed below. Thank you for your time.
>>Sincerely,
>Kim - Oregon
><kimberla at teleport.com>
>>>--
>kimberla at teleport.COM Public Access User -- Not affiliated with Teleport
>Public Access UNIX and Internet at (503) 220-1016 (2400-28800, N81)
Hoping to have been of some help. If you need more explanation, please contact me
at:
d.orsini at elsevier.nl
Good luck,
Daniela
