>Not necessarily, there is quite a bit of evidence that some cytokines may be
>translocated to the nucleus, following binding to their receptor, so making
>distinctions between hormones on this basis may not hold.
>Steve Hopkins
>ok steve, give me a ref for anything like this at all! What cytokines are
>translocated to the nucleus? assuredly il 1-15 all bind a membrane bound
>receptor (usually a heterodimer or heterotrimer) and in that way transduce a
>signal. ive never even seen a hint of the idea that any cytokine may appear
>in the nucleus of a cell (excluding dna, or transfected molecules with a
>retention sequence)
> but i'd love a reference!
>Ralph M. Bernstein
>ok steve, give me a ref for anything like this at all! What cytokines are
>translocated to the nucleus? assuredly il 1-15 all bind a membrane bound
>receptor (usually a heterodimer or heterotrimer) and in that way transduce a
>signal. ive never even seen a hint of the idea that any cytokine may appear
>in the nucleus of a cell (excluding dna, or transfected molecules with a
>retention sequence)
>> but i'd love a reference!-email me
>
Sorry it's taken so long but, in addition to the post from Rachel Teitelbaum you
might like to try these:
1. Burwen SJ, Jones AL. The association of polypeptide hormones and growth
factors with nuclei of target cells. TIBS 1987;12:159-62.
2. Maier JAM, Statuto M, Ragnotti G. Endogenous interleukin 1 alpha must be
transported to the nucleus to exert its activity in human endothelial
cells. Mol Cell Biol 1994;14:1845-51.
3. Wessendorf JHM, Garfinkel S, Zhan X, Brown S, Maciag T. Identification of
a nuclear localization sequence within the structure of the human
interleukin-1 precursor. J Biol Chem 1993;268:22100-4.
4. Weitzmann MN, Savage N. Nuclear Internalisation and DNA Binding Activities
of Interleukin-1, Interleukin-1 Receptor and Interleukin-1/Receptor
Complexes. Biochem Biophys Res Commun 1992;187:1166-71 (Academic Press,
Inc, 1250 Sixth Ave, San Diego, CA 92101).
5. Grenfell S, Smithers N, Miller K, Solari R. Receptor mediated endocytosis
and nuclear transport of human interleukin 1 . Biochem J 1989;264:813-22.
6. Heguy A, Baldari C, Bush K, et al. Internalization and Nuclear
Localization of Interleukin-1 Are Not Sufficient for Function. Cell Growth
Different 1991;2:311-5.
I'm sure there is more, but I don't have it to hand.
Good reading.
Steve Hopkins
