T-cell hybridomas
AMRUT S BHOGLE
AMRUT at OITVMS.OIT.UMASS.EDU
Sat Feb 18 14:36:50 EST 1995
dear Readers,
Pardon my ignorance. I was reading a paper from Nature Feb. 2, 1995 on
Fas-Fas ligand interaction leading to apoptosis in a T-cell hybridoma A1.1
(Activation induced cell death). I realize that the cell-line (hybridoma) A1.1
seems to be producing interleukin-2 as well as has cytolytic activity -- it
kills (lyses) Fas-ligand transfected cell-lines. I wonder how could a
functionally mature T-cell have a phenotype of both helper and cytolytic
lymphocytes. Is this a normal phenomenon?
Thanks.
Amrut
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