HIV and TCell Numbers/Memory

Tue Feb 21 15:03:06 EST 1995

Lots of mouse data says the thymus functions well in adults.  Irradiated 
mice reconsituted with bone marrow become noramlly responsive pretty 
quickly, as do humans (about a year for people).  Thymectomized mice 
irradiated and bm reconsituted do not develope T cell funtion,  so the 
thymus must work even though it involutes.

On Tue, 21 Feb 1995, David Peritt wrote:

> In article <ralph.1143705994A at> Ralph M Bernstein,
> ralph at writes:
> >question: where the hell are those tcell being made?  everyone knows that
> >aafter or at puberty the thymus involudes-we are left with a very poor
> >education system.  w/out the thymic education we run the risk of
> >autoimmunity/ect.  so what goes on here?  it cannot be tcells that
> havenot
> >encountered antigen in the perhiphery, since they die in around 72h after
> >release if they dont encounter ag.  evenbetter, i dont think it could be
> >from expanding memory cells because they would be infected any way-like a
> >roachmotel, in hiv infected lymphnodes, tcells go in but they dont go
> out.  
> It is surmized with little data that peripheral T cells expand to fill
> the void.  There is little evidence for extrathymic generation of new T
> cells (except for those gut g/d cells).  Whether it is naive or memory T
> expanding is unknown to me.  What I am saying is that I do not think it
> is known but yes it is a very basic immunology question.  In fact, the
> reason I posted the homeostasis question was partially due to your
> question.  If peripheral T's are proliferating they must get a signal to
> do so when T levels drop.  What may that be????  This question could be
> answered by someone with nimble fingers willing to do the proper Tx
> experiments of naive and memory T in athymic mice.   You put different
> amount of T in and see who proliferates to compensate.  It may have been
> done but us human Immunologist never get to do many Tx exps and therefore
> never read these papers which can be done so elegantly partially out of
> jeolousy.

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