HIV and TCell Numbers/Memory
Ralph M Bernstein
ralph at ccit.arizona.edu
Mon Feb 20 17:12:34 EST 1995
I have a question for those thymic-t cell people out there that is actually
related to the recent t-cell number/ HIV questions posted.
background: the recent article in science or nature -i'm not sure-
hypothesized that HIV and Tcell production are fighting a long drawn out
battle where the HIV eventually wins. eg the body produces tcells ALMOST
fast enough to keep even with the viral-induced killing.
question: where the hell are those tcell being made? everyone knows that
aafter or at puberty the thymus involudes-we are left with a very poor
education system. w/out the thymic education we run the risk of
autoimmunity/ect. so what goes on here? it cannot be tcells that havenot
encountered antigen in the perhiphery, since they die in around 72h after
release if they dont encounter ag. evenbetter, i dont think it could be
from expanding memory cells because they would be infected any way-like a
roachmotel, in hiv infected lymphnodes, tcells go in but they dont go out.
i dont know the answer, and i'm frustrated that i dont know such a seemingly
basic immunological answer... everyone feel free to respond or email me.
we've had some good discussions so far-dont let me down. thx Ralph.
Ralph M. Bernstein
Dept of Micro/Immuno
University of Arizona
Ph: 602 626 2585
Fx: 602 626 2100
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