HIV and TCell Numbers/Memory
Peritt_d at a1.mscf.upenn.edu
Tue Feb 21 17:03:25 EST 1995
In article <Pine.3.89.9502211437.A132967-0100000 at UNCVX1.OIT.UNC.EDU> ,
JAF at UNCVX1.OIT.UNC.EDU writes:
>Lots of mouse data says the thymus functions well in adults. Irradiated
>mice reconsituted with bone marrow become noramlly responsive pretty
>quickly, as do humans (about a year for people). Thymectomized mice
>irradiated and bm reconsituted do not develope T cell funtion, so the
>thymus must work even though it involutes.
The question is not whether the thymus is essential in BM Tx. This is
obviously true since the pre-T's must transverse the thymus to mature.
The question is if you Tx mature T cells into irr athymic mouse will
these cells populate the mouse by proliferating to fill the T cell void?
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