Jorg Kirberg kirberg at
Fri Feb 24 18:10:26 EST 1995

In article <ming-2402951054200001 at>,
ming at (Ding Ming) wrote:

> Hi,
> Can someone here enlighten me some important references on how TCR was
> hunted at the very biginning? i.e., how and by what experiment did people
> realize that the heterodimetric T-cell receptor was the surface receptor
> to recognize foreign antigens by T lymphocytes?

Hi Ding,
actually I cant answer your question, but out of curiosity I would like
to ask the people responding about another thing a "bit" related:

Werent there some data arguing that the T cell receptor is actually
immunoglobin ? I once had heard that this statement was made, and that
it was actually published in quite acceped journals.
Is this true, whom did so and what was the basis of their argumentation ?
Were these data ever cleaned up (say retracted) if published ?

Just interested how science went those days (not that long ago anyhow),


P.S.: I am aware of the proof that the genes found were relevant for the
specificity of T cells. There was a paper in Nature from Z. Dembic and
M. Steinmetz (the one whom killed the I-J story of suppressor cell restriction)
and others showing that transfection of a and b genes was sufficient to
transfer specificity. Should be easy to locate with medline.


Joerg Kirberg                     EMAIL: kirberg at
Basel Institute for Immunology    FAX:   41-61-605 13 72
Grenzacherstr. 487                PHONE: 41-61-605 12 77 (lab)
CH-4005 Basel


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