question on IgA role in preventing allergies

kinjs kinjs at
Thu Jan 19 20:24:11 EST 1995

If it is true that IgA could neutralize allergins, then is it feasible
to to try to stimulate IgA production to certain allergens rather than
innoculate a person with an allergin? Maybe hay fever could be
alleviated by the patient taking regular doses of pollen allegins
orally. The capsule could be such that it would open up and empty out
its contents (eg. pollen allergins) in due to a certain chemical
environment found near the M cells which uptake the antigen. If this
could stimulate IgA production, then it would do so for all the mucuos
membranes, thus an airborn allergin could be taken orally to stimulate
the production of IgA specific to that allergin in the mucous membranes
lining the upper and lower respiratory tract - there would be lots of
scenarios. What about the importance of IgG neutralization (IgG binds
to the molecule leading to the allergic response and prevents it from
being able to bind to basophils/mast cells)? Uptake of antigen by the M
cells in the gut would lead to the production of IgG cells? Maybe the
reason that we get used to allergins is not soley because of less
number of mast cells, but really because of the optimal production of
IgA? Well, could not the branchial patch lining part of the lung take
up the allergin and stimulate IgA production? Yes, but maybe ashma
patients have trouble absorbing allergins into their branchial patch
because of a thicker mucous layer? Basically, do you think oral intake
of certain allergins could theoretically stop or diminish
substantially, allergic reactions?

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