oral tolerance vs immunity

Ralph M Bernstein ralph at ccit.arizona.edu
Mon Jul 10 16:18:54 EST 1995

In Article <3ts200$cid at netnews.upenn.edu>, David Peritt 

<Peritt_d at a1.mscf.upenn.edu> wrote:

>In article <gregoryh-0807951317020001 at> Gregory R.
>Harriman, gregoryh at bcm.tmc.edu writes:
>>>         Oral tolerance most often refers to T cell tolerance (TH1). 
>I have never heard that TH1 cells were the mediators of oral tolerance. 
>In fact it is more of a TH2 like response or as some investigators
>suggest TH3 (which is high TGFb producer).

    i think what that statement may have meant was that the Th1's are the
cells tolerized, not the cells doing the tolerization.   because that would
be what you want to "knock out", for example i think that in the case of MS,
the Th1 response is what is killing you.     

    regards, ralph
Ralph M. Bernstein
Dept of Micro/Immuno
University of Arizona
Ph: 602 626 2585
Fx: 602 626 2100
url: http://lamprey.medmicro.arizona.edu

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