TH1 vs TH2

kruskal at RASCAL.MED.HARVARD.EDU kruskal at RASCAL.MED.HARVARD.EDU
Thu Jul 20 14:16:41 EST 1995


In article <x1IggBo.aguldo at delphi.com>, bogleb <aguldo at delphi.com> writes:
> 
>Can someone please explain the features of a TH1 vs a TH2 immune
>response?  I gather that a TH1 cell is more of a cytokine-producing
>cell, while a TH2 cell is more directly involved in encouraging
>antibody production in a B cell.  A list of relevant cytokines and
>cell surface markers would be nice to know, too.  Thanks.

Here are two nice brief review articles:
1.	Mosmann, T.R. and R.L. Coffman,  TH1 and TH2 cells: different patterns
of lymphokine secretion lead to different functional properties. Ann. Rev.
Immunol., 1989. 7: p. 145-173.
2.	Romagnani, S., Induction of TH1 and TH2 responses: a key role for the
'natural' immune response? [see comments]. Immunology Today, 1992. 13(10): p.
379-81.
________________________________
Benjamin A. Kruskal, MD, PhD
Division of Infectious Diseases
The Children's Hospital
300 Longwood Ave.
Boston, MA  02115
617-355-5152
617-355-6575 (fax)
kruskal at a1.tch.harvard
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