LPS toxicity

Kenneth Grandchamp grandcha at cmu.unige.ch
Tue Jun 6 13:53:11 EST 1995


I would like to know what is the acceptable limits of LPS 
contamination in preparations administered parenterally in 
experimental animals. In particular, in experiments using 
cytokines as modulators of the immune response in rats. 
I am aware that sensitivity to LPS varies with the source of LPS, 
genetic background of the animal and level of induced tolerance 
to LPS. Despite these variables, is there a limit 
for LPS contamination acceptable in the kind of experiments 
described above.

 
Thank you. 

S. Ilangumaran
Univ. Geneva.
E-mail:IN%"Ilanguma at cmu.unige.ch"
 



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