real function, type/tope, tolerance.
bryan_fisk at gyn.mda.uth.tmc.edu
Tue Jun 13 10:43:58 EST 1995
> then to dr fuchs question again
>>Just because I cannot think of any way that the immune system can
>>distinguish between idiotypes and foreign antigens does not mean that
>>there is no such mechanism. Therefore I repeat, can anyone provide me
>>with an acceptable answer to this question?
> the tcells that are reactive to those identicle epitopes or
>idiotopes are deleted in the thymus. these tcells dont reach the
>perhiphery to react with a b cell.
I thought T-cells were educated in the thymus upon thymic epithelium and
not B-cells? Also, since each T- and B-cell has a clonotypic, rearranged
receptor, from which idiotopes may arise, wouldn't each T-cell have to
be tolerized against each B-cell idiotope? I don't see how that could be
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