re real function, naive bcells

Ephraim Fuchs ejf at
Tue Jun 13 21:27:42 EST 1995

Dr M.R. Clark (mrc7 at wrote:

: I accept fully that the logical way out of this is to say that a naive B-cell
: presents for tolerance. However what about activated B-cells undergoing somatic
: hypermutation. Experimental evidence shows us that activated B-cells make
: highly efficient antigen presenters. So how do you deal with altered 
: specificity
: and idiotype during hypermutation?

The solution that Polly Matzinger and I have arrived at is that both 
resting and activated B cells are tolerogenic APCs for naive but not 
memory T cells.  We believe that all experiments showing activated B 
cells as good APCs used responder T cells that contain some memory cells 
(even from T cell receptor transgenic mice).

By not allowing naive T cells to become activated by antigens presented 
by B cells, the idiotype presentation problem is avoided.

Ephraim Fuchs
ejf at

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