re real function, naive bcells

Ralph M Bernstein ralph at ccit.arizona.edu
Tue Jun 13 22:30:44 EST 1995


In Article <3rlheu$r8i at jhunix1.hcf.jhu.edu>, ejf at welchlink.uoregon.edu
(Ephraim Fuchs) wrote:

>Dr M.R. Clark (mrc7 at cus.cam.ac.uk) wrote:
>
>: I accept fully that the logical way out of this is to say that a naive B-cell
>: presents for tolerance. However what about activated B-cells undergoing
>:somatic
>: hypermutation. Experimental evidence shows us that activated B-cells make
>: highly efficient antigen presenters. So how do you deal with altered 
>: specificity
>: and idiotype during hypermutation?
>
>The solution that Polly Matzinger and I have arrived at is that both 
>resting and activated B cells are tolerogenic APCs for naive but not 
>memory T cells.  We believe that all experiments showing activated B 
>cells as good APCs used responder T cells that contain some memory cells 
>(even from T cell receptor transgenic mice).
>
>By not allowing naive T cells to become activated by antigens presented 
>by B cells, the idiotype presentation problem is avoided.
>
>Ephraim Fuchs
>ejf at welchink.welch.jhu.edu
>
    
    Is this correct:

    so what i think that drs fuchs and matzinger are now saying is that
there are no anti-idiotypic antibodies in normal people (since to have an
antiidiotypic secondary response you must have t cell help-and in their
scenario, there cannot be  T-cells specific for b cell idiotypes).  hint:
there _are_ anti-idiotypic antibodies in normals.

    regards, ralph

Ralph M. Bernstein
Dept of Micro/Immuno
University of Arizona
Ph: 602 626 2585
Fx: 602 626 2100



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