Platelet GPIV

George W Chacko gchacko at magnus.acs.ohio-state.edu
Thu Jun 15 10:10:14 EST 1995


In article <beaubien-1506950809120001 at pppa.ftn.net>,
Beatrice Beaubien <beaubien at ftn.net> wrote:

>There is much debate, and some readers of this group have more insights
>than I. However, just from the platelet point of view it appears to be
>involved in the second wave of aggregation, and auto-antibodies to GPIV
>(or CD36 as it is also called) may mediate different types of
>thrombocytopenia.

It seems likely that auto-antibodies against CD36 may activate
platelets by clustering the Fc receptor for IgG on platelets through a
two point interaction, i.e. Fab binding CD36 and Fc binding FcgR.

GC



More information about the Immuno mailing list