Role of B7/BB1 and CD28 in T cell mediated cytotoxicity
Dmartin at uctgsh1.uct.ac.za
Tue Jun 20 08:03:15 EST 1995
I have read about the importance of costimulatory molecules
(B7/BB1 and CD28) for initial stimulation of T cells. I was
wondering about the role played by these molecules in the
recognition and killing phase of the cytotoxic T cell ie.
once the T cell has been stimulated to proliferate by a
particular antigen, will that T cell be able to recognize
and kill a target cell presenting the same antigen to it
without the presence of the costimulatory molecules.
E-mail: JPASSMOO at UCTGSH1.UCT.AC.ZA
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