Role of B7/BB1 and CD28 in T cell mediated cytotoxicity

D.Martin Dmartin at uctgsh1.uct.ac.za
Tue Jun 20 08:03:22 EST 1995


Hello,

I have read about the importance of costimulatory molecules 
(B7/BB1 and CD28) for initial stimulation of T cells.  I was 
wondering about the role played by these molecules in the 
recognition and killing phase of the cytotoxic T cell ie. 
once the T cell has been stimulated to proliferate by a 
particular antigen, will that T cell be able to recognize 
and kill a target cell presenting the same antigen to it 
without the presence of the costimulatory molecules.

Thanks

Jo-Ann Passmore
E-mail: JPASSMOO at UCTGSH1.UCT.AC.ZA




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