Complement activity

DANDERSON at PRL.PULMONARY.UBC.CA DANDERSON at PRL.PULMONARY.UBC.CA
Fri Jun 23 09:14:41 EST 1995


I have sent this request before and will send this last time.  If 
anyone has any thoughts or comments, thanks!

I am interested in cobra venum factor (CVF) as a molecule to deplete the 
complement pathway in mice.  If I deplete with  a couple of 
injections over a day or two, what are the effects of the cleavage 
products of "this" C3 convertase.  How long does the it take for the 
effects of C3a to return to baseline.  Are Mono's and Mac's (other APCs)
chemotactively activated for 1 hour, 4 hours, 24 hours, 3 days or is 
this known???  What are the effects of such cleavage products on 
phagocytosis and other functions, and again how long are such effects 
sustained??    

I am into medline and text's but have not found any clear data  
addressing this issue.  Any comments or suggestions would be great!

Thanks in advance!

Dan Anderson
The University of British Columbia
The Univeristy of Nebraksa Medcial Center



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