? for immunology friends

Shahram Mori smori at nmsu.edu
Thu Mar 9 22:52:17 EST 1995


: Dear immuno/HIV netters,
: I know that In vivo there has not been any evidence of HIV infection of CD8+ve
: cells. These are the results from Dr Levy's lab who couldn't isolate HIV
: genome from CD8 cells of HIV-infected individuals using PCR. Also it is known
: that CD8+ve cells isolated from HIV-infected individuals die in vitro together
: with CD4+cells by apoptosis after activation.
: My 1st question is 1) Do you believe that CD8+ve cells are infectable by HIV?
: 2) How is it that they die by apoptosis [ especially if they are not
: infected]?
: Are CD8 cells dependant on cytokine factors for viability which may be
: abnormal due to infection of T-helper and macrophages?
: Please post so that everybody can get involved.
: Cheers 
:  --
: Shahram Mori.



: We recently discussed the paper in journal club (I'mnot sure if this is 
: the one your are referring to)concerning HIV-mediated apoptosis of cells 
: in human thymic xenografts in scid mice.  In those mice it appeared most 
: if not all thymic subpopulations were infected.  This is not really my 
: area, but does HIV normally access the thymus?  If iit does, can it 
: infect DP thymocytes (via CD4)?  Finally,if that were to occur, after 
: selection on class I, wouldn't you have a lot of infected CD8's floating 
: around?

: Bill

HIV has access to the Lymphoid tissue and therefore the Thymus. But I didn't
know that HIV could infect CTL's. I thought the dysfunctionality of CTL's
was due to the aberrations in communication of Th/MPhages with CTL's as caused
by HIV. But I can definitely see that at the stage of double+ve cells HIV
can infect the progenitor CD8 cells. But I would guess that this occurs at
low numbers because HIV tends to infect activated cells rather than
resting T-cells right? Can all the immunologists jump in here please?
Cheers
--
Shahram Mori					   _/\_
Program in Molecular Biology			  _\  /_
Dept. of chemistry and Biochemistry Box 3C	  \_  _/
NMSU  Las Cruces NM				    ||
88003





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