Will there ever be a Vaccine to HIV?

Steve Goldberg msgold at ix.netcom.com
Fri Mar 10 20:24:12 EST 1995


In <D530C7.FwC at midway.uchicago.edu> your name here 
<yourname at yourmachine.uchicago.edu> writes: 

>
>mic2mcb at leeds.ac.uk (M.C. Bean) wrote:
>>
>> gy,sci.med,sci.med.aids
>> Approved: Yes: Jeff Rizzo <biomech at telerama.lm.com>,jfh at crl.com (Jack 
Hamilton)
>> Subject: Will there ever be a Vaccine to HIV?
>> Message-ID: <21636 at sci.med.aids>
>> Reply-To: mic2mcb at leeds.ac.uk
>> Date: Sun, 26 Feb 1995 05:23:12 CDT
>> Organization: University of Leeds
>>  
>> I  am a final year student of microbiology at the University of Leeds 
and i am
>> co-ordinating research for a forcoming debate on HIV in our medical
>> microbiology class. The motion that we are debating is "This house 
believes
>> that there will never be a vaccine for HIV. The group which I am 
working for
>> is in favour of the motion (randomly allocated). We have already come 
up with
>> the rate of HIV mutation and consequent antigenic variation, the
>> transmissability of HIV cell to cell which can shield it from the 
serum
>> antibodies and some stuff about the presentation of epitopes to 
T-cytotoxic
>> cells that we are still trying to understand.
>>  
>> Does anybody out there have any opinions of there own on this subject 
that
>> they would like to discuss or any suggestions for lines of research 
which we
>> could follow from here?
>>  
>> Thanks in advance
>>  
>> Matt
>
>

Matt, are you aware of the encouraging nef deleted SIV strain that 
protects macaques from SAIDS? (Science 258:1938 - 1992)...I am not aware 
of any follow up studies on comparable HIV attenuated strains, however. 
Also, obviously any potential live HIV vaccine would be difficult to 
introduce into clinical trials...Any one have thoughts or further info. 
on this?
Monica




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