Inhibition of Apoptosis in T Cells

Esteban Celis cytel1 at cerfnet.com
Mon Mar 20 14:32:22 EST 1995


Does anyone have any suggestions on how to block antigen-induced apoptosis
observed in human CTL lines (and clones) in culture?

 A major problem that immunologists face when trying to grow long-term CTL
lines is that after 3-4 cycles of antigen-restimulation (using peptides and
APC) the CTL die. Many think that this death is the result of Fas/Fas ligand
reactions that the antigen stimulation induces in the cell cultures. Are
there any drugs that would inhibit Fas ligand mediated apoptosis whithout
inhibiting cell growth of the CTL??



More information about the Immuno mailing list