TH3 cells?

derek chan chan4 at fas.harvard.edu
Wed Mar 22 19:35:03 EST 1995


In article <3kps5u$1ea at netnews.upenn.edu>,
David Peritt  <Peritt_d at a1.mscf.upenn.edu> wrote:
>In article <3kolh2$b8k at styx.uwa.edu.au> Alec Redwood,
>aredwood at uniwa.uwa.edu.au writes:
>>: Can anyone tell me about TH3 cells and/or direct me to an article. 
>
>
>These cells were coined by those working in EAE model.  They found high
>TGFb producers when fed MBF orally.  The cells did not fit into neat TH1
>or TH2 so they coined the term.  I think this is bunk.  There is no clear
>Th1 or Th2 anyway.  These cells are far more versatile than those in
 ^^^^^^^^^^

Huh?!?

CD4+ TH1 cells have decidedly different cytokine production than CD4+TH2 
cells.  There is evidence that one cell type can downregulate the other 
cell type (or phenotype, if you think they are the same cell).  However, 
it's interesting to note that Fas Ligand-mediated cytoxicity/apoptosis is 
mediated by TH1 CD4+ cells and not the TH2 CD4+ cells (This doesn't 
exclude the CD8+ cells from carrying on a non-calcium 
dependent/Fas-dependent mechanism of lysis of target cells, of course.) 



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