TH3 cells?

Unknown Unknown
Tue Mar 28 08:50:07 EST 1995

In article <3kuifv$368 at>, David Peritt <Peritt_d at> says:
>In article <3kqfnn$s0o at> derek chan,
>chan4 at writes:
>I must redeem myself.  I believe there are Th2 and Th1 tendencies in CD4
>T cells.  I just do not believe it is so cut and dry as the murine
>leishmaniaisis data suggests.  We work in human T cells and find a
>rainbow of T cells producing tons of gINF and no IL-4 all the way to tons
>of IL-4 and low gIFN.  But 95% of the cells are in between.  and If you
>look broader at IL4,5,6,10 etc... you see that when IL4 is high IL5 or 10
>may not be and vice versa.  does this mean we have Th3 or th6 cells. 
>NOOOOOOO.  What we have are independently regulated cytokine genes.  Our
>lab has shown for instance that gIFN is increased by IL-12
>administration.  Therefore even a Th2 looking cell will make tons of gIFN
>if IL-12 is added.  In that same paper we show that IL-12 added at the
>time of first priming actually stabally increases IFN production-for the
>life of the cell.  
>So, what I am saying is the following.  Don't be too dogmatic with this
>Th1 vs 2 thing.  Th0 is used to explain these intermediates but it is
>much messier.  I have begun to present my clonal data in linear form
>assigning the clones a gINF/IL4 ratio of production.  Therefore a Th1
>like cell will be a 600 and a Th2 a .3.  You get the picture.  
>The beauty of the immune system is not the perfectness but the slop. 
>Slop allows the immune system to recognize and adapt so well.  Dogma is
>good to get us started and thanks to tim Mossman for that but it is time
>to dive into the slop.  Pleasant swimming.


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