In vitro recombination

Andrei Popov ANDREI.POPOV at bbsrc.ac.uk
Sat Nov 11 18:43:57 EST 1995


>Does anyone know if in B-cell differentition,  the D-J recombination and
>the Variable Heavy-DJ recombination reactions have been successfully
>performed in-vitro.  A friend of mine said that he thought Dr. Stuart
>Kauffman of the Santa Fe Institute has done this, but I haven't been
>able to find any references on this.  Any help would be greatly
>appreciated.    

No. It has not been done.
M.Sadofsky (spell?) and coauthers published 
a couple of months ago in Cell a paper on V(D)J recombination
in vitro but.... it was very far away from total success.





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