How many CD4/CD8 molecules per cell?
Keith R. Kuhn
kkuhn at pennet.net
Sat Nov 11 17:53:02 EST 1995
In article <47m6rd$8bs at newsbf02.news.aol.com>,
alussow at aol.com (ALussow) wrote:
>Can anyone tell me how many CD4 or CD8 molecules there
are on the
>corresponding murine or human T-cell?? What is the
surface area of the
>If you don't ask much from life, that's what you'll get.
An interesting and difficult question. Also a relatively
one as far as clinical applications.
At this time I can only propose to work around an answer.
cell diameter range that T cells far into is 9-12 microns.
cells, such as immature basophils, also fall into this
one wants to assume a sphere that you can calculate from
diameter. Electronic cell counters measure volumne in
femtoliters. This is true with RBCs. I seem to remember
somewhere that T cell volume is between 140 and 160
(but need shape to calculate surface area), but I have no
reference to support this. Just to be sure that we are on
same page, I want memtion that one cannot classify a cell
volume. Electronically derived WBC differentiatials use
as part of the classification. The volume used however
be found in the manufacture's software algrithm. Such
are appearently company secrets.
As to the number of CD4 & CD8 receptors this would vary
maturity and possibly with TCRs. As TCRs are continuously
replaced so might CD4 & CD8. I do not think that anyone
the answer to your question. I would like to guess that
it is in
the hundreds. Someone out there correct me!
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