Strange behaviour of two antibodies:help!

Giorgio Spagnol spagnol at galactica.it
Sun Nov 12 05:23:15 EST 1995


Dear fellow researchers,
I'm studying two antibodies, which have the peculiarity of staining the 
cytoplasm or the nucleus of neural cells. They do this both on on frozen 
tissue slides and on cultured cells.
For such a staining to occur, I presume that the antibody should first 
bind to a membrane receptor, than be internalized. This can occur when a 
Fc receptor is present, but, to my knowledge, neural cell do not have 
such a receptor. Does anybody know examples of internalization of 
antibodies outside the immune system, or can give an explanation for the 
behaviour of these two antibodies?
I would be very grateful for any advice.
Thanks in advance.
Giorgio





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