Protein drugs and immune response

NATARAJ at UNIVSCVM.CSD.SCAROLINA.EDU NATARAJ at UNIVSCVM.CSD.SCAROLINA.EDU
Wed Nov 29 11:42:51 EST 1995


Hi,
   I am working on developing several bacterial enzymes for cancer therapy.
They have good therapeutic charateristics like long plasma half life in mice.
We are limited by antibody-mediated inactivation of these enzymes during
repeated treatment cycles.  We are trying to shield them from antibody-mediated
inactivation by attaching PEG to the lysine residues.  This has increased the
therapeutic life of these enzymes two fold.  Also it increases the serum half-
life to 72 hours!  Are there better ways of preventing antibody-mediated
inactivation of therapeutic proteins?  Are there efficient ways of inducing
tolerance to a specific protein?  Any help in this subject would be greatly
appreciated.  Thanks.
                     Natarajan



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