A question of LPS

brett brett at BORCIM.WUSTL.EDU
Tue Nov 28 21:07:57 EST 1995


>Hello,
>
>I am a graduate student working on a paper that involves cellular
>activation in response to lipopolysaccharide, and I am not sure as to how
>this stuff gets phagocytosed. Does it have to be bound with IgG (i.e.,
>opsonized), or can a macrophage just decide it doesn't like the looks of
>it and do a non-specific phagocytosis? If the latter is true, what
>receptors if any are involved in recognizing LPS in the medium? I am
>specifically interested in the Fc-gamma RI,II, and III receptors. 
>
>TIA, 
>Dan Chehebar

Sorry, won't do your homework for you. But, check out Medline for CD14, the
LPS receptor. Interesting properties include a GPI anchor to the membrane,
association with src-family members like Hck, and a shed form which can
facilitate signaling in other cells. I do recall an Annual Review of Imm.
on this subject within the past two years.



Brett Lindenbach
    
Program in Immunology                              
Washington University - St Louis                  
brett at borcim.wustl.edu                             

"I own my own pet virus. I get to pet and name her." - Cobain




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