APC targeted Ag: can it direct Th1 or Th2 responses

R M Bernstein ralph at ccit.arizona.edu
Mon Oct 2 12:48:04 EST 1995

In Article <Pine.HPP.3.91.951001211734.10202A-100000 at fhs.csu.McMaster.CA>,
Denis Snider <sniderd at fhs.csu.McMaster.CA> wrote:
>On 28 Sep 1995, William F. Wade wrote:
>> What evidence is there, if any, that targeting antigen to a specific
>> internalization pathway or APC type favors a Th1 vs Th2-type response. >
>        I've been doing studies on antigen targetting in vitro and in 
>vivo for the last few years.  I have seen nothing in the literature that 
>answers your question directly.  So far as is known now, Th1 and Th2 are 
>more determined by the nature of the cytokine microenviroment available 
>during the initial response of the naive Th precursor.  For instance 
>IL-12 and IFN-gamma promote Th1 and IL-4 promotes Th2.  However, it is 
>known that the best APC for proper activation of Th precursors is the 
>dendritic cell or an activated B cell.  That is from in vitro (no in 
>direct in vivo evidence yet) work by among others Drs. S.Swain, T. 
>Mossman, Seder, and others, published mostly in JI, JEM, etc/ 
>        Good luck.  Let me know if you find more useful information.
>Denis Snider   PhD
>Associate Professor
>Dept. of Pathology
>McMaster University

related to this topic,
has anyone seen anymore data on the ability of b71 and b72 to serve as
markers to determine the th1 / th2 commitment of t cells?
regards, ralph

Ralph M. Bernstein
Dept of Micro/Immuno
University of Arizona
Ph: 602 626 2585
Fx: 602 626 2100
url: http://lamprey.medmicro.arizona.edu

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