balpat at aol.com (Balpat) wrote:
>Can anyone explain to me the origin of isohemagglutinin antibodies
>(Anti-A, Anti-B)? Are they always IgM isotype? Why don't the B cells
>producing the isohemagglutininis undergo class switching to another
>isotype?
>>JP
Naturally occurring anti-A and anti-B isohemagglutinins are made in
response to A-like and B-like polysaccharide antigens on environmental
bacteria.
Isohemaggultinins may be IgM, IgG, or IgA. Most individuals have a
mixture of IgG and IgM, but virtually any combination may be seen.
For more infromation see: Mollison. Blood Transfusion in Clinical
Medicine. 9th ed. Blackwell Scientific Publications
--
Robertson D. Davenport, MD
Assistant Professor Associate Medical Director
Department of Pathology Blood Bank and Transfusion Service
University of Michigan Medical School University of Michigan Hospitals
rddvnprt at umich.edu
