APC targeted Ag: can it direct Th1 or Th2 responses

Laszlo Radvanyi radvanyi at oci.utoronto.ca
Wed Oct 4 19:21:29 EST 1995

On Mon, 2 Oct 1995, R M Bernstein wrote:

> In Article <Pine.HPP.3.91.951001211734.10202A-100000 at fhs.csu.McMaster.CA>,
> Denis Snider <sniderd at fhs.csu.McMaster.CA> wrote:
> >On 28 Sep 1995, William F. Wade wrote:
> >> What evidence is there, if any, that targeting antigen to a specific
> >> internalization pathway or APC type favors a Th1 vs Th2-type response. >
> >William,
> >        I've been doing studies on antigen targetting in vitro and in 
> >vivo for the last few years.  I have seen nothing in the literature that 
> >answers your question directly.  So far as is known now, Th1 and Th2 are 
> >more determined by the nature of the cytokine microenviroment available 
> >during the initial response of the naive Th precursor.  For instance 
> >IL-12 and IFN-gamma promote Th1 and IL-4 promotes Th2.  However, it is 
> >known that the best APC for proper activation of Th precursors is the 
> >dendritic cell or an activated B cell.  That is from in vitro (no in 
> >direct in vivo evidence yet) work by among others Drs. S.Swain, T. 
> >Mossman, Seder, and others, published mostly in JI, JEM, etc/ 
> >
> >        Good luck.  Let me know if you find more useful information.
> >
> >Denis Snider   PhD
> >Associate Professor
> >Dept. of Pathology
> >McMaster University
> related to this topic,
> has anyone seen anymore data on the ability of b71 and b72 to serve as
> markers to determine the th1 / th2 commitment of t cells?
> regards, ralph
> Ralph M. Bernstein
> Dept of Micro/Immuno
> University of Arizona
> Ph: 602 626 2585
> Fx: 602 626 2100
> url: http://lamprey.medmicro.arizona.edu
>      http://radon.gas.uug.arizona.edu/~bernster

Check an article in a recent issue of "Immunity" (May or June issue) by 
Lee Nadler's group.  They claim that B7-2 is required for IL-4 secretion, 
I'm not mistaken.

Laszlo Radvanyi
Ontario Cancer Institute,
Toronto, Ontario M4X 1K9

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