size of Ab H chain V region?

R M Bernstein ralph at
Fri Oct 6 12:35:21 EST 1995

In Article <199510061545.IAA18380 at>, dmullins at (David W.
Mullins) wrote:
>How long is the V region of an Ab H chain?
>Some say 113, others 123 amino acid residues?
>What is the correct (or *most current*) answer?  Please help!
>Thanks for your assistance,
>David W. Mullins, Ph.D. Student
>Department of Biology, Microbiology and Immunology Section
>Virginia Polytechnic Institute and State University (Virginia Tech)
>Blacksburg, VA  24061-0406
>Lab     (540) 231-8933
>Fax     (540) 231-9307

it depends on the cdr length.  so both are probably correct.  the cdrs ,
especially of igm's , can be huge.  if you go to Dr.TT Wu's homepage, where
he has all the kabat and wu stuff set up, you can paruse the vhs of any
creature extant! (and cloned).

regards, ralph

Ralph M. Bernstein
Dept of Micro/Immuno
University of Arizona
Ph: 602 626 2585
Fx: 602 626 2100

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