IgG vs IgM

Robert C. Newton Robert_C._Newton at dmpcfc.com
Tue Oct 17 15:33:00 EST 1995


     I would opt to perform the comparison on the basis of weight of material
injected.  Most therapeutics are administered on a mg/kg or mg/m2 basis so
that the amount of material to inject can be reasonably determined.  In
addition, and in deference to the current interest of the health care
networks, the cost comparison is always generated on a $ per mg basis.  
     Terms such as molar concentrations can only be accurately used in vitro
- the term has little meaning in vivo except in back of the envelope
extrapolations from blood concentrations.  This again is only meaningful if a
peak blood level needs to be achieved (such as with an irreversible enzyme or
receptor inhibitor) as opposed to an extended time of exposure.
     The other reason for opting for a weight comparison is that comparing
IgG and IgM action is like apples and oranges.  They can both be found in the
fruit aisle but are different purchases.  They have evolved two different
strategies to achieve their respective effects.  A simple combining site for
combining site comparison ignore the basic differences in this strategy.  

Bob



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