Synthetic Gla-containing peptides

Jim Sadowski Sadowski_VK at HNRC.Tufts.edu
Fri Oct 20 10:19:35 EST 1995


I am interesting in synthesizing some peptides that are homologous to
the calcium binding gla domains of vitamin K dependent proteins.  Does
anybody know of anyone who has been able to insert gla residues into
synthetic peptides?  Gla is the following amino acid and is formed from
glutamic acid in a post-translational event requiring vitamin K, oxygen
and carbon dioxide....gamma-carboxyglutamic acid or 1-carboxyglutamic
acid.  Thanks.

Jim Sadowski, Ph.D.
Jean Mayer USDA Human Nutrition Research Center on Aging
Tufts University
711 Washington Street
Boston, MA 02111
(617) 556-3151
Sadowski_VK at Mint.HNRC.Tufts.edu








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