Immunodeficiency in DM
jcherwon at dres.dnd.ca
Fri Oct 27 15:05:14 EST 1995
Dear Kenichiro Kashihara:
You may get a few replies on how diabetes influences the immune response
as a result of high glucose affecting white blood cells and hence antigen
processing and immunological response.
However, I'd like to add perhaps a novel "twist" to this occurrence.
Possibly hormones play a direct role on micro-organisms. In the case of
diabetes, it has been found that Pseudomonas pseudomallei is inhibited by
insulin. People with normal insulin levels are more resistant to infection
(D.E. Woods et al., 1993, Interaction of insulin with Pseudomonas
pseudomallei, Infection and Immunity, 61(1)4045-4050). In a reverse situation,
in the case of brucellosis, the bacterium grows better in the presence of
reproductive hormones and causes a stimulation of these hormones after the 5th
month of pregnancy in cattle (Samartino and Enright, 1991, 45th Annual
brucellosis Conference, Chicago). Hormones may play a role directly on the
invading bacteria rather than on the host.
Hope this helps...John
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