Interesting question re: APC & T cell

mdcabl at mdcabl at
Fri Sep 1 06:24:04 EST 1995

Hi all,

I had this question come up in journal club and didn't have clue how to answer
it. I can't find anything in medline but that doesn't mean much.  The question
was: after TCR engagement of the MHC/peptide, how do the APC and T cell let go?
And, which cell "gets" the peptide.  It was speculated that either the TCR or
MHC gets cleaved, maybe both... In which case, the molecules might become
soluble?  Anybody have an idea or want to speculate?

Allen Black
Dept. of Pathology
Univ. of Newcastle

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