Interesting question re: APC & T cell
Aaron J. Mackey
ajmackey at artsci.wustl.edu
Fri Sep 1 18:55:36 EST 1995
In article <427rhj$37u at cisunix1.dfci.harvard.edu>,
Ian A. York <york at mbcrr.dfci.harvard.edu> wrote:
>Further, the TcR is generally down-regulated by contact with MHC (shown
>most convincingly for CD4 cells, but likely true as well for CD8). One
>potential and very interesting outcome of this is discussed in -
>Valitutti S. S., et al., Nature 375:148-151 (1995)
>M.M. David, Natuure 375:104 (1995)
This is, as Dr. Jim Allison calls it, the toilet-paper model of T cell
activation - one after another TcR binds to the same MHC molecule and
then goes away (?), allowing another TcR to "roll" into place.
Regardless of how weird it sounds, it's more physiological than the
currently held crosslinking model . . . just my 2 cents.
P.S. In no way does this reflect the thinking of my peers and professors
at Wash U! They would disagree with me entirely . . .
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