Signal transduction by ClassI MHC

Ingrid Jakobsen ingrid at
Fri Sep 22 23:48:37 EST 1995

In article <43tij7$hon at>, kelso at (Janet Kelso) writes:
|> I was wondering if any research has been done on whether or not the 50
|> kilodalton cytoplasmic domain of the class I MHC plays a role in signal
|> transduction. If so, what is the outcome of the signal?
|> Just interested...anyone got any ideas?

All I know is there's a Tyr which can be phosphorylated by 
pp60(v-src) and is quite conserved.
(Guild et al  PNAS 80: 2894-98  1983)
Does anyone know if this was followed up or if anything else 
has been done since?


Ingrid Jakobsen at           
Human Genetics Group                  
John Curtin School of Medical Research
Australian National University.	
P.O. Box 334   Canberra, ACT 2601      

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